Golden Retriever-PRA 1 (GPRA1)

Progressive Retinal Atrophy (Golden Retriever Type1)

Turnaround: 3-5 days

US: $45.00 | UK: £40.00

Breeds: Double Doodle, Golden Retriever, Goldendoodle, Miniature Goldendoodle


Progressive Retinal Atrophy (PRA) is a category of genetic mutations that cause vision loss and blindness. Photoreceptor cells (light-sensing cells) in the retina begin to degenerate, typically progressing from a loss of night vision to complete blindness.

PRA affects many different dog breeds, and these mutations are breed-specific. In Golden Retrievers, two mutations have been identified (in addition to prcd-PRA) known as GR-PRA1 and GR-PRA2.

Both GR-PRA1 and GR-PRA2 are inherited autosomal recessive disordersAutosomal recessive disorders are disorders that can be passed from either parent and require two copies of the gene to show symptoms. Because both GR-PRA1 and GR-PRA2 are recessive disorders, a dog must have two copies of the mutation in order for the disease to manifest. This means that a dog can have one copy of the mutation and not experience any signs or symptoms of GR-PRA1 or GR-PRA2. This dog would be known as a carrier. The carrier can then pass on either the normal gene or the mutated gene to any offspring. If two carriers are bred, there is a 25% per puppy that they will develop symptoms of GR-PRA1 or GR-PRA2.


Downs LM, Wallin-Hakansson B, Boursnell M, Marklund S, Hedhammar A, Truve K, Hubinette L, Lindblad-Toh K, Bergstrom T, Mellersh CS. A frameshift mutation in golden retriever dogs with progressive retinal atrophy endorses SLC4A3 as a candidate gene for human retinal degenerations. PLoS One. 2011;6(6):e21452. [PubMed: 21738669]

Possible Results

P/PAffected: Dog has two copies of the GR-PRA1 mutation and will be affected. The mutation will be passed to every offspring.
n/PCarrier: Dog has one copy of the GR-PRA1 mutation. The dog is not affected by GR-PRA1 but may pass the mutation to offspring.
n/nClear: Dog is negative for the mutation associated with GR-PRA1.