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Breeds: All
Description
Lhasa Apso Albinism (LAA) is an oculocutaneous albinism found in small breeds. Affected dogs have white or off-white fur, pink skin, pale or blue eyes and a depigmented nose, lips and foot pads. Although dogs with this condition lead a relatively normal life, they can be prone to light sensitivity and melanocytic tumors. Unlike some other forms of albinism, hearing loss is not a symptom of this disorder.
A missense variant (c.1478G>A) in the SLC45A2 gene is the primary cause of albinism in several small dog breeds, including the French Bulldog, German Spitz, Lhasa Apso, Pekingese, Pomeranian and Pug, as well as mixed breeds. In the French Bulldog and Pug this variant is often referred to as “pink.”
The c.1478G>A variant is not responsible for albinism in other types of dogs, including the Bullmastiff and Doberman Pinscher. Albinism in those breeds is caused by other variants in the same gene: a single base deletion in the Bullmastiff and a large deletion in the Doberman Pinscher. Additional variants in SLC45A2 have been identified in humans, gorillas, cattle and other species with oculocutaneous albinism.
Possible results
| Genotype | Description |
|---|---|
| A/A | Albino: Dog has two copies of the allele causing albinism in some small breeds and will express the albino phenotype. |
| n/A | Carrier: Dog has one copy of the allele causing albinism in some small breeds. |
| n/n | Clear: Dog is negative for the allele causing albinism in some small breeds. |
Breeds Affected
French Bulldog, German Spitz, Lhasa Apso, Pekingese, Pomeranian, Pug
Reference
A Missense Mutation in SLC45A2 Is Associated with Albinism in Several Small Long Haired Dog Breeds.
[PMID: 25790827]