Muscular dystrophy Landseer type (MD-LS) is an inherited disease causing progressive muscle weakness. MD-LS is caused by a variant in COL6A1-gene encoding collagen type VI. The symptoms associated with this disease are similar to Muscular Dystrophy affecting Golden Retriever dogs. Affected dogs develop problems with gait, arched back and the pelvic limbs are placed under the abdomen. Skeletal muscles of the limbs become atrophied and a decreased range of motion occurs. Affected dogs suffer from increased joint pain are generally euthanized at 5 to 15 months of age.
A Nonsense Variant in COL6A1 in Landseer Dogs with Muscular Dystrophy G3 (Bethesda). 2015 Oct 4;5(12):2611-7. doi: 10.1534/g3.115.021923. Steffen F, Bilzer T, Brands J, Golini L, Jagannathan V, Wiedmer M, Drögemüller M, Drögemüller C, Leeb T.[PMID: 20686772]
|MD/MD||Affected: Dog has two copies of the Muscular Dystrophy mutation and will be affected. The gene will be passed on to every offspring.|
|n/MD||Carrier: Dog has one copy of the Muscular Dystrophy mutation. The dog will not be affected by MD but may pass the mutation to offspring.|
|n/n||Clear: Dog is negative for the mutation associated with Muscular Dystrophy.|