Chondrodysplasia (CDPA) is a general term used to describe a genetic trait that affects the skeleton’s development of cartilage growth plates. It is generally characterized by a normal sized body and shorter-than-normal limbs.
Animal Genetics offers testing for both CDDY and CDPA mutations. The current list of dogs with either CDDY and/or CDPA is not complete and will expand as more testing is completed. CDDY is considered a semi-dominant trait, meaning that dogs with 2 copies of the CDDY mutation are smaller than dogs with only 1 copy of the mutation. CDPA is a dominant trait, meaning that dogs only need a single copy to be affected and to be susceptible to IVDD. Dogs that test positive for both CDDY and CDPA have shorter legs. Research is ongoing to determine if dogs that test positive for CDDY and CDPA are more prone to IVDD then dogs that test positive for only IVDD. Testing can help identify if the dog is at risk for IVDD by distinguishing short legged dogs with CDPA from those with CDDY.
|C/C||Affected: Dog has two copies of CDPA mutation and will have shorter legs compared to n/n dogs. The gene will be passed on to every offspring.|
|N/C||Affected: Dog is a carrier for the CDPA mutation and will have shorter legs compared to n/n dogs.|
|N/N||Clear: Dog is negative for the CDPA mutation.|
Emily A. Brown, Peter J. Dickinson, Tamer Mansour, Beverly K. Sturges, Miriam Aguilar, Amy E. Young, Courtney Korff, Jenna Lind, Cassandra L. Ettinger, Samuel Varon, Rachel Pollard, C. Titus Brown, Terje Raudsepp, and Danika L. Bannasch
FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs Proc Natl Acad Sci U S A. 2017 Oct 24; 114(43): 11476–11481. [PMID: 29073074]