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Breeds: American Corgi, Australian Labradoodle, Belgian Malinois, Belgian Tervuren, Boykin Spaniel, British Labrador Retriever, Cardigan Welsh Corgi, Chesapeake Bay Retriever, Clumber Spaniel, Cockapoo, Cocker Spaniel, Corgipoo, Curly-Coated Retriever, Double Doodle, English Cocker Spaniel, Flat-Coated Retriever, German Longhaired Pointer, German Shorthaired Pointer, German Wirehaired Pointer, Giant Schnauzer, Labradoodle, Labrador Retriever, Miniature Schnauzer, Mixed Breed, Mixed Breed (Dog), Old English Sheepdog, Pembroke Welsh Corgi, Sheepadoodle, Standard Schnauzer, Unspecified, Unspecified Breed
Exercise-Induced Collapse (EIC) disorder is an autosomal recessive genetic disorder causing affected dogs to suffer from a loss of muscle control following periods of extreme exercise. Autosomal recessive genetic disorders are disorders that can be passed from either parent and require two copies of the gene to show symptoms. Typically, an affected dog begins to show symptoms between 5 months and 3 years of age. This is usually the age that more intensive training begins, especially for agility or working dogs.
EIC episodes generally occur after 5-25 minutes of extreme exercise. Not all types of exercise can induce an attack; generally the dog must be actively running and excited for an extended period of time. The attacks often begin with rocking, followed by the hind limbs becoming weak and giving out. The severity of these attacks ranges between dogs. Some dogs will continue to attempt to retrieve, dragging their hind legs along, and other will be totally unable to move, acting disoriented. These attacks usually only last about 5-25 minutes, however, in some extreme cases, dogs have died immediately following an EIC attack.
Dogs with Exercise-Induced Collapse can still lead full lives. However, it is important for dog owners to be familiar with what types of activities a dog can participate in and what types of games may trigger an episode.
Because EIC is a recessive disorder, a dog must have two copies of the mutation in order for the disease to manifest. This means that a dog can have one copy of the mutation and not experience any signs or symptoms of EIC. This dog would be known as a carrier. The carrier can then pass on either the normal gene or the mutated gene to any offspring. If two carriers are bred, there is a 25% per puppy that they will develop symptoms of EIC.
Minor KM, Patterson EE, Keating MK, Gross SD, Ekenstedt KJ, Taylor SM, Mickelson JR. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J. 2011 Aug; 189(2):214-9. [PubMed: 21782486]
Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet. 2008 Oct; 40(10):1235-9. [PubMed: 18806795]
|EIC/EIC||Affected: Dog has two copies of the mutation associated with Exercise-Induced Collapse and will pass a copy to every offspring.|
|n/EIC||Carrier: Dog has one copy of the Exercise-Induced Collapse mutation. The dog is not affected by EIC but may pass the gene to offspring.|
|n/n||Clear: Dog is negative for mutation associated with Exercise-Induced Collapse.|