Musladin-Lueke Syndrome (MLS)

Description

Musladin-Leuke Syndrome (MLS) is a recessive mutation that affects Beagles. Recessive mutations are mutations that can be passed from either parent and require two copies of the gene to show symptoms. The mutation prevents normal formation of the skin and connective tissue, affecting the dog's appearance and walk. 

A beagle with MLS may be smaller in size and walk on his toes rather than on the pad of the foot. Other symptoms include a flattened head shape, tight and stiff fur, and slanted eyes. A wide range of severity is associated with MLS, so some dogs may experience mild to moderate symptoms. Others, however, may be severely impaired. There is no cure for MLS. This condition is not fatal, though some dogs affected by MLS may also experience seizures. Proper veterinary care can help maintain a positive quality of life for dogs affected by MLS. 

The mutation causing MLS is autosomal recessive, meaning that both parents would have to contribute a copy of the mutation to produce offspring with MLS. Carriers of the mutation are asymptomatic; genetic testing can identify these carriers to prevent breeding puppies with MLS. If two carriers are bred together, there is a 25% chance per puppy that they will develop MLS.