Cystinuria Type 3 Associated Marker (variant 3)

French Bulldog Cystinuria

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Breeds: Alapaha Blue Blood Bulldog, Australian Bulldog, British Bulldog, Bulldog, Bullmastiff, English Bulldog, English Mastiff, French Bulldog, French Mastiff, Mastiff, Miniature English Bulldog, Miniature Olde English Bulldog, Neapolitan Mastiff, Olde English Bulldogge, Southern Cross Bulldog, Tibetan Mastiff


Cystinuria is a genetic disorder that can affect some dog breeds, including French Bulldogs. It's essential to differentiate between different types and variants of Cystinuria, including Type 3 variants 2 and 3, as they may have distinct genetic mutations and clinical implications. Here's an overview of Cystinuria Type 3 variants 2 and 3 in French Bulldogs:

Cystinuria Type 3 Variant 2: Cystinuria Type 3 Variant 2 is a specific genetic variation associated with the disorder. It results in the impaired transport of amino acids, including cystine, in the kidneys and urinary tract. Dogs with this variant may be at greater risk of forming cystine stones in their urinary tract, which can lead to urinary problems.

Cystinuria Type 3 Variant 3: Cystinuria Type 3 Variant 3 is another specific genetic variation related to Cystinuria in dogs. Like other Cystinuria variants, it involves the disruption of amino acid transport in the kidneys and urinary tract, potentially leading to the formation of cystine stones.

Common Aspects:

• Both variants of Cystinuria Type 3 are hereditary conditions and are more common in specific dog breeds, including French Bulldogs.

• Affected dogs may display similar symptoms, such as recurrent urinary tract infections, painful urination, blood in the urine, and, in severe cases, urinary obstruction.

• Diagnosis typically involves clinical examination, urinalysis, and imaging studies to identify the presence of cystine stones. Genetic testing can confirm the specific variants responsible for Cystinuria.

Treatment and Management: The treatment and management of Cystinuria Type 3 variants 2 and 3 in French Bulldogs are generally similar to other types of Cystinuria. This includes dietary modifications, increased water intake, and the use of medications to reduce cystine levels in the urine. In some cases, surgical intervention may be necessary to remove cystine stones and address urinary obstructions.

Prevention: Preventing the transmission of Cystinuria Type 3 variants 2 and 3 in French Bulldogs requires responsible breeding practices. Breeders should screen their breeding dogs for these specific genetic mutations and avoid mating dogs that are carriers of the condition. By doing so, breeders can help reduce the risk of Cystinuria in their breeding lines and promote the overall health of the French Bulldog population.

If you have a French Bulldog that may be at risk of Cystinuria or if you are considering breeding, consulting with a veterinarian or a genetic counselor with expertise in canine genetics is highly recommended. They can provide guidance on genetic testing, breeding strategies, and overall management of this hereditary disorder in the breed.

Possible Results

Genotype Description
CY/CY Dog has two copies of the variant somewhat linked to cystinuria in bulldogs.
n/CY Dog has one copy of the variant somewhat linked to cystinuria in bulldogs.
n/n Dog is negative for variant somewhat linked to cystinuria in bulldogs.


Harnevik L, Hoppe A, Soderkvist P. SLC7A9 cDNA cloning and mutational analysis of SLC3A1 and SLC7A9 in canine cystinuria. Mamm Genome. 2006 Jul;17(7):769-76. [PubMed: 16845473]