Pug Dog Encephalitis (PDE), or Necrotizing Meningoencephalitis (NME), is an aggressive and fatal inflammatory disease of the central nervous system.
The average age that signs of the disease appear is 18 months, but some dogs are diagnosed as young as 6 weeks of age and others as old as 9 years. Affected dogs generally suffer from progressive neurological problems including circling, seizures, depression, ataxia, abnormal gait, and blindness. Although not all of these signs are seen in every dog, most affected dogs become lethargic and depressed. When several of these signs occur together in a young adult Pug, particularly seizures, loss of coordination, and lethargy, PDE is suspected.
Pugs that are homozygous for PDE have a higher chance of developing symptoms of PDE. Those that are heterozygous for PDE are known as carriers. Carriers can pass on the PDE gene to offspring. When breeding with another carrier, there is a 25% chance that the offspring will be homozygous for PDE and develop symptoms.
|Dog has two copies of the DLA type associated with a increased risk of developing PDE.
|Dog has one copy of the DLA type associated with a increased risk of developing PDE.
|Dog is negative for the DLA type associated with a increased risk of developing PDE.
Identification of Novel Genetic Risk Loci in Maltese Dogs with Necrotizing Meningoencephalitis and Evidence of a Shared Genetic Risk across Toy Dog Breeds
Isabelle Schrauwen, Renee M. Barber, Scott J. Schatzberg, Ashley L. Siniard, Jason J. Corneveaux, Brian F. Porter, Karen M. Vernau, Rebekah I. Keesler, Kaspar Matiasek, Thomas Flegel, Andrew D. Miller, Teresa Southard, Christopher L. Mariani, Gayle C. Johnson, Matthew J. Huentelman [PMID: 25393235\]