Skeletal Dysplasia 2 (Labrador Retriever dwarfism type)
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Price: $45.00Price: £40.00
Breeds: Australian Labradoodle, British Labrador Retriever, Double Doodle, Goldador, Goldador Doodle, Labradoodle, Labrador Retriever, Mixed Breed, Unspecified
Description
Canine Skeletal Dysplasia 2 (SD2) is a mild form of disproportionate dwarfism found in Labrador Retrievers. It is generally characterized by one or more body parts being smaller in comparison to the overall size of the animal. Animals with SD2 develop legs that are shorter than unaffected legs, despite a normal body size. In most cases, the front legs are more severely affected than the hind legs. This causes an awkward stance and gait.
The SD2 variant is associated with disproportionate dwarfism in Labrador Retrievers and has displayed subtle effects. Unlike other forms of skeletal dysplasia, SD2 is not associated with any vision or hearing problems. Studies suggest that field or working lines of Labrador Retrievers are more likely to inherit the SD2 variant.
In most cases the affected males had shoulder heights of less than 55 cm and affected females had shoulder heights of less than 50 cm. The international breed standard is 56-57 cm for males and 54-56 cm for females.
Possible Results
| Genotype | Description |
|---|---|
| SD2/SD2 | Affected: Dog has two copies of the Skeletal Dysplasia 2 mutation and will be affected. The mutation will always be passed on to every offspring. |
| n/SD2 | Carrier: Dog carries one copy of the mutation associated with Skeletal Dysplasia 2. |
| n/n | Clear: Dog is negative for the mutation associated with Skeletal Dysplasia 2. |
Reference
Frischknecht M, Niehof-Oellers H, Jagannathan V, Owczarek-Lipska M, Drogemuller C, Dietschi E, Dolf G, Tellhelm B, Lang J, Tiira K, Lohi H, Leeb T. A COL11A2 mutation in Labrador Retrievers with mild disproportionate dwarfism. PLoS One. 2013;8(3):e60149 [PubMed: 23527306]