Progressive Retinal Atrophy (crd2)

Progressive Retinal Atrophy Cone Rod Dystrophy (Type 2)

Turnaround: 3-5 business daysTurnaround: 7-10 business days

Price: $45.00Price: £40.00

Breeds: American Bully, American Staffordshire Terrier, Exotic Bully, Mixed Breed, Pit Bull Terrier, Unspecified


Progressive Retinal Atrophy, cone-rod dystrophy 2 (PRA-crd2) is an inherited eye disease affecting certain breeds of dogs as early as 12 weeks of age. The disease affects the cells of the Retina known as Photoreceptor Cells causing thinning of the retinal tissue. The aggressive nature of the disease results in the loss of vision over the next 12-20 months of age.

Possible Results

Genotype Description
crd2/crd2 Affected: Dog has two copies of the PRA-rcd2 mutation and will be affected. The mutation will always be passed on to every offspring.
n/crd2 Carrier: Dog carries one copy of the mutation associated with PRA-rcd2. Dog will not be affected by PRA-rcd2 but may pass the mutation to offspring.
n/n Clear: Dog is negative for the mutation associated with rcd2.


Goldstein O, Mezey JG, Schweitzer PA, Boyko AR, Gao C, Bustamante CD, Jordan JA, Aguirre GD, Acland GM. IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds. Invest Ophthalmol Vis Sci. 2013 Oct 25;54(10):7005-19. [PubMed: 24045995]

Kijas JW, Zangerl B, Miller B, Nelson J, Kirkness EF, Aguirre GD, Acland GM. Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies. Mol Vis. 2004 Mar 29;10:223-32. [PubMed: 15064680]